Retin-A cream (tretinoin cream) is usually applied once daily in the evening on clean, completely dry skin. Wash your face with a mild cleanser, pat it dry, and wait about 20–30 minutes before applying the cream, as damp skin can increase irritation. Take a small pea-sized amount and spread a thin layer over the affected area, avoiding the eyes, lips, corners of the nose, and any broken or irritated skin. When starting treatment, it is often recommended to use it every other night for the first few weeks and then increase to nightly use if your skin tolerates it well. Because tretinoin can make the skin more sensitive to sunlight, apply a moisturizer if needed and use a broad-spectrum sunscreen with SPF 30 or higher during the day. Mild redness, dryness, or peeling can occur in the beginning, but these effects often improve as the skin adjusts to the treatment. Always follow the instructions provided by your healthcare professional for the strength and frequency that are right for you.